Wear a Condom: Use Bcc!
It happens time and time again, and some people only learn the hard way. I was called at home late this evening because an internal company memo with a poll had been mailed To: fifty or sixty recipients, and one of them answered the questions with a reply to all. It is a bit of a shame that the answers he or she gave, appear to have been unsuitable for all to see…
Could I do something about it? Nope. Shit happens. Bad luck, mate! We can't go digging into people's mail files looking for a message to delete. And anyway, on who's orders? With the laws in this country, doing stuff like that is completely out of the question, quite apart from the fact that I consider it unethical.
Think before you write: use blind carbon copy (Bcc), to protect yourself and others.

I created this app for just that reason.
http://www.openntf.org/Projects/pmt.nsf/ProjectHome?ReadForm&Query=ASND%20Mass%20Mailer
Originally, it was built to save the HR people from maintaining groups in the address book, but a later enhancement allowed individual emails to be sent without killing the router task with a huge BCC list. You might want to look to implement it at your site.
Sean—
Thank you Sean; I'll have a look at it.